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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13137 | TGFβRI-IN-1 | TGF-beta/Smad | |
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ). | |||
T9523 | TGFβRI-IN-3 | TGF-beta/Smad | |
TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1]. | |||
T61203 | ALK5-IN-8 | ||
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently... | |||
T60931 | TGFβRI-IN-5 | ||
TGFβRI-IN-5 (Compound 4b) is a potent TGFβRI inhibitor with an IC50 of 0.08 μM. TGFβRI-IN-5 shows amazing anticancer activity against all the tested cell lines which enhances apoptosis and arrested G2/M phase of cell cyc... |